VGKC antibody-associated encephalitis, microbleeds and progressive brain atrophy
نویسندگان
چکیده
منابع مشابه
Focal CA3 hippocampal subfield atrophy following LGI1 VGKC-complex antibody limbic encephalitis
Magnetic resonance imaging has linked chronic voltage-gated potassium channel (VGKC) complex antibody-mediated limbic encephalitis with generalized hippocampal atrophy. However, autoantibodies bind to specific rodent hippocampal subfields. Here, human hippocampal subfield (subiculum, cornu ammonis 1-3, and dentate gyrus) targets of immunomodulation-treated LGI1 VGKC-complex antibody-mediated li...
متن کاملNon-paraneoplastic limbic encephalitis associated with NMDAR and VGKC antibodies.
INTRODUCTION Limbic encephalitis (LE) is characterised by seizures and impairment of short-term memory as well as behavioural and psychiatric symptoms such as anxiety, depression, personality change and hallucinations. Onset of these symptoms is typically subacute over a few weeks or months but may also evolve over a few days. In many patients, limbic encephalitis is a paraneoplastic syndrome u...
متن کاملNMDA Receptor Antibody Associated Encephalitis: Unexplained Encephalitis
Introduction N-methyl D-aspartate (NMDA) receptors are glutamate receptors and responsible for controlling memory function and synaptic plasticity. 1 Activation of these receptors requires binding with glutamate or aspartate. These receptors are present in the limbic system, hypothalamus, and forebrain. 2 Binding of antibodies to these receptors lead to their removal from synaptic sites, thus l...
متن کاملAnti-Ma2 associated paraneoplastic neurological syndrome presenting as encephalitis and progressive muscular atrophy.
A 36 year old man with a history of testicular germ cell tumour presented six months after bilateral orchidectomy with progressive amnesia, irritability, vertical gaze palsy, and generalised seizures. Eight months after initial onset of symptoms, he demonstrated a head drop with muscular atrophy of the upper limbs, shoulder girdle, and posterior neck. He reported no sensory disturbances and his...
متن کاملDelayed LGI1 seropositivity in voltage-gated potassium channel (VGKC)-complex antibody limbic encephalitis
We utilise a clinical case to highlight why exclusion of voltage-gated potassium channel (VGKC)-complex autoantibody testing in serological evaluation of patients may delay or miss the diagnosis. A 68-year-old man presented with increasing involuntary movements consistent with faciobrachial dystonic seizures (FBDS). Initial evaluation demonstrated VGKC antibody seropositivity with leucine-rich ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurology
سال: 2009
ISSN: 0340-5354,1432-1459
DOI: 10.1007/s00415-009-5370-5